BDBM22952 CHEMBL73572::Indomethacin derivative, 5::methyl 2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetate

SMILES COC(=O)Cc1c(C)n(C(=O)c2ccc(Cl)cc2)c2ccc(OC)cc12

InChI Key InChIKey=OKHORWCUMZIORR-UHFFFAOYSA-N

Data  2 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 22952   

TargetProstaglandin G/H synthase 1(Sheep)
Vanderbilt University School of Medicine

LigandPNGBDBM22952(CHEMBL73572 | methyl 2-{1-[(4-chlorophenyl)carbony...)
Affinity DataIC50: 3.30E+4nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2008
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Vanderbilt University School of Medicine

LigandPNGBDBM22952(CHEMBL73572 | methyl 2-{1-[(4-chlorophenyl)carbony...)
Affinity DataIC50: 250nMT: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2008
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Vanderbilt University School of Medicine

LigandPNGBDBM22952(CHEMBL73572 | methyl 2-{1-[(4-chlorophenyl)carbony...)
Affinity DataIC50: 3.30E+4nMAssay Description:In vitro inhibitory activity against ovine Prostaglandin G/H synthase 1 (44 nM) using [14C]AA (50 uM) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Vanderbilt University School of Medicine

LigandPNGBDBM22952(CHEMBL73572 | methyl 2-{1-[(4-chlorophenyl)carbony...)
Affinity DataIC50: 250nMAssay Description:In vitro inhibitory activity against human Prostaglandin G/H synthase 2 (66 nM) using [14C]-AA (50 uM) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member C2(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22952(CHEMBL73572 | methyl 2-{1-[(4-chlorophenyl)carbony...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant AKR1C2-mediated NADP+-dependent oxidation of S-(+)-1,2,3,4-tetrahydro-1-naphtholMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member C3(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22952(CHEMBL73572 | methyl 2-{1-[(4-chlorophenyl)carbony...)
Affinity DataIC50: 5.67E+3nMAssay Description:Inhibition of human recombinant AKR1C3-mediated NADP+-dependent oxidation of S-(+)-1,2,3,4-tetrahydro-1-naphtholMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM22952(CHEMBL73572 | methyl 2-{1-[(4-chlorophenyl)carbony...)
Affinity DataKi:  4.02E+3nMAssay Description:Evaluated for binding affinity against recombinant human peripheral cannabinoid receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetCannabinoid receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM22952(CHEMBL73572 | methyl 2-{1-[(4-chlorophenyl)carbony...)
Affinity DataKi: >2.00E+4nMAssay Description:Evaluated for binding affinity against recombinant human central cannabinoid receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article