BDBM228644 US10111875, Compound 105::US10369153, Compound 105::US9346810, 105

SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(C#N)c(F)c1

InChI Key InChIKey=UIBBXLYNSIGGKF-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 228644   

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM228644(US9346810, 105 | US10111875, Compound 105 | US1036...)
Affinity DataIC50: 14nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM228644(US9346810, 105 | US10111875, Compound 105 | US1036...)
Affinity DataIC50: 48.7nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM228644(US9346810, 105 | US10111875, Compound 105 | US1036...)
Affinity DataIC50: 359nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM228644(US9346810, 105 | US10111875, Compound 105 | US1036...)
Affinity DataIC50: 0.0550nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Hutchinson Medipharma

US Patent
LigandPNGBDBM228644(US9346810, 105 | US10111875, Compound 105 | US1036...)
Affinity DataIC50: 14nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Hutchinson Medipharma

US Patent
LigandPNGBDBM228644(US9346810, 105 | US10111875, Compound 105 | US1036...)
Affinity DataIC50: 48.7nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Hutchinson Medipharma

US Patent
LigandPNGBDBM228644(US9346810, 105 | US10111875, Compound 105 | US1036...)
Affinity DataIC50: 359nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Hutchinson Medipharma

US Patent
LigandPNGBDBM228644(US9346810, 105 | US10111875, Compound 105 | US1036...)
Affinity DataIC50: 100nMAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Hutchinson Medipharma

US Patent
LigandPNGBDBM228644(US9346810, 105 | US10111875, Compound 105 | US1036...)
Affinity DataIC50: 14nMAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Hutchinson Medipharma

US Patent
LigandPNGBDBM228644(US9346810, 105 | US10111875, Compound 105 | US1036...)
Affinity DataIC50: 48.7nMAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Hutchinson Medipharma

US Patent
LigandPNGBDBM228644(US9346810, 105 | US10111875, Compound 105 | US1036...)
Affinity DataIC50: 359nMAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent