BDBM228619 US9345789, Z-DEVD-FMK

SMILES COC(=O)CC[C@H](NC(=O)[C@H](CC(=O)OC)NC(=O)OCc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)OC)C(=O)CF

InChI Key InChIKey=GBJVAVGBSGRRKN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 228619   

TargetCaspase-3(Mouse)
Stanford University

LigandPNGBDBM228619(US9345789, Z-DEVD-FMK)
Affinity DataIC50: 130nMpH: 7.4 T: 2°CAssay Description:IC50 measurements and enzyme kinetics assays were performed on a Spectramax M5 fluorescent plate reader (Molecular Devices).More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2011
Entry Details Article
PubMed
TargetCaspase-3(Human)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM228619(US9345789, Z-DEVD-FMK)
Affinity DataIC50: 130nMpH: 5.8Assay Description:Assay buffers consist of 20 mM citric acid, 60 mM disodium hydrogen orthophosphate, 1 mM EDTA, 0.1% CHAPS, 4 mM DTT, pH 5.8 for legumain, 50 mM dihyd...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
Go to US Patent

TargetReplicase polyprotein 1ab(2019-nCoV)
National Institutes of Health

LigandPNGBDBM228619(US9345789, Z-DEVD-FMK)
Affinity DataIC50: 6.81E+3nMAssay Description:The 3CLpro enzyme assay was developed in 384-well black, medium binding microplates (Greiner Bio-One, Monroe, NC, USA) with a total volume of 20 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
National Institutes of Health

LigandPNGBDBM228619(US9345789, Z-DEVD-FMK)
Affinity DataIC50: 10nMAssay Description:Primary assay principle based on quenched FRET peptide substrate of SARS-CoV-2 3CL-Pro (lhs). Inhibiting compounds reduce fluorescence signal relativ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
National Institutes of Health

LigandPNGBDBM228619(US9345789, Z-DEVD-FMK)
Affinity DataIC50: 10nMAssay Description:Primary assay principle based on quenched FRET peptide substrate of SARS-CoV-2 3CL-Pro (lhs). Inhibiting compounds reduce fluorescence signal relativ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details Article