BDBM22826 2,3-dioxo-2,3-dihydro-1H-indole-7-carboxylic acid::CHEMBL375078::Isatin-based compound, 46

SMILES OC(=O)c1cccc2C(=O)C(=O)Nc12

InChI Key InChIKey=ROODQCZSWXEDJL-UHFFFAOYSA-N

Data  6 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 22826   

TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM22826(2,3-dioxo-2,3-dihydro-1H-indole-7-carboxylic acid ...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant DNA ligase 1 by radioactive gel-based ligation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM22826(2,3-dioxo-2,3-dihydro-1H-indole-7-carboxylic acid ...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of human recombinant DNA ligase 1 using nicked DNA substrate by kinetic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
St. Jude Research Hospital

LigandPNGBDBM22826(2,3-dioxo-2,3-dihydro-1H-indole-7-carboxylic acid ...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
St. Jude Research Hospital

LigandPNGBDBM22826(2,3-dioxo-2,3-dihydro-1H-indole-7-carboxylic acid ...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Rabbit)
St. Jude Research Hospital

LigandPNGBDBM22826(2,3-dioxo-2,3-dihydro-1H-indole-7-carboxylic acid ...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
St. Jude Research Hospital

LigandPNGBDBM22826(2,3-dioxo-2,3-dihydro-1H-indole-7-carboxylic acid ...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCholinesterase(Human)
St. Jude Research Hospital

LigandPNGBDBM22826(2,3-dioxo-2,3-dihydro-1H-indole-7-carboxylic acid ...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed