BDBM228232 1-((1s,4s)-4-hydroxycyclohexyl)-3-methyl-8-(1-phenyl-1H-pyrazol-4-yl)-1H-imidazo[4,5-c]quinolin-2(3H)-one::US10047084, 21::US9328099, 40-64

SMILES Cn1c2cnc3ccc(cc3c2n([C@@H]2CC[C@H](O)CC2)c1=O)-c1cnn(c1)-c1ccccc1

InChI Key InChIKey=IWWZJMKINULDRT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 228232   

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM228232(US10047084, 21 | 1-((1s,4s)-4-hydroxycyclohexyl)-3...)
Affinity DataIC50: 2nMT: 2°CAssay Description:The reactions employed a common peptide substrate, LCB-EQEDEPEGDYFEWLW-NH2 (in-house). The basic assay protocol is as follows: First, 250 nL of dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM228232(US10047084, 21 | 1-((1s,4s)-4-hydroxycyclohexyl)-3...)
Affinity DataIC50: 0.0500nMT: 2°CAssay Description:The reactions employed a common peptide substrate, LCB-EQEDEPEGDYFEWLW-NH2 (in-house). The basic assay protocol is as follows: First, 250 nL of dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Beijing Forelandpharma

US Patent
LigandPNGBDBM228232(US10047084, 21 | 1-((1s,4s)-4-hydroxycyclohexyl)-3...)
Affinity DataIC50: 55nMAssay Description:The inhibition of the mTOR protein kinase activity by the compounds was determined by the enzymatic activity assay in vitro. The detection kit suppli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details
Go to US Patent