BDBM228229 1-((1s,4s)-4-hydroxycyclohexyl)-8-(6-methoxyl-5-methylpyridin-3-yl)-3-methyl-1H-imidazo[4,5-c]quinolin-2(3H)-one::BDBM229429::US10047084, 20::US9328099, 40-53

SMILES COc1ncc(cc1C)-c1ccc2ncc3n(C)c(=O)n([C@@H]4CC[C@H](O)CC4)c3c2c1

InChI Key InChIKey=YHEIXGQEWFJVFA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 228229   

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM228229(US10047084, 20 | 1-((1s,4s)-4-hydroxycyclohexyl)-8...)
Affinity DataIC50: 20nMT: 2°CAssay Description:The reactions employed a common peptide substrate, LCB-EQEDEPEGDYFEWLW-NH2 (in-house). The basic assay protocol is as follows: First, 250 nL of dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM228229(US10047084, 20 | 1-((1s,4s)-4-hydroxycyclohexyl)-8...)
Affinity DataIC50: 1.50E+3nMT: 2°CAssay Description:The reactions employed a common peptide substrate, LCB-EQEDEPEGDYFEWLW-NH2 (in-house). The basic assay protocol is as follows: First, 250 nL of dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM228229(US10047084, 20 | 1-((1s,4s)-4-hydroxycyclohexyl)-8...)
Affinity DataIC50: 0.600nMT: 2°CAssay Description:The reactions employed a common peptide substrate, LCB-EQEDEPEGDYFEWLW-NH2 (in-house). The basic assay protocol is as follows: First, 250 nL of dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM228229(US10047084, 20 | 1-((1s,4s)-4-hydroxycyclohexyl)-8...)
Affinity DataIC50: 400nMT: 2°CAssay Description:The reactions employed a common peptide substrate, LCB-EQEDEPEGDYFEWLW-NH2 (in-house). The basic assay protocol is as follows: First, 250 nL of dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Beijing Forelandpharma

US Patent
LigandPNGBDBM228229(US10047084, 20 | 1-((1s,4s)-4-hydroxycyclohexyl)-8...)
Affinity DataIC50: 55nMAssay Description:The inhibition of the mTOR protein kinase activity by the compounds was determined by the enzymatic activity assay in vitro. The detection kit suppli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details
Go to US Patent