BDBM228210 3-methyl-8-(6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)-1-(1-methylpyrrolidin-3-yl)-1H-imidazo[4,5-c]quinolin-2(3H)-one::US10047084, 9::US9328099, 40-37

SMILES CN1CCC(C1)n1c2c(cnc3ccc(cc23)-c2ccc(nc2)-c2cnn(C)c2)n(C)c1=O

InChI Key InChIKey=MRYXQEWYPNZMLN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 228210   

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM228210(US10047084, 9 | 3-methyl-8-(6-(1-methyl-1H-pyrazol...)
Affinity DataIC50: 506nMT: 2°CAssay Description:The reactions employed a common peptide substrate, LCB-EQEDEPEGDYFEWLW-NH2 (in-house). The basic assay protocol is as follows: First, 250 nL of dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2017
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM228210(US10047084, 9 | 3-methyl-8-(6-(1-methyl-1H-pyrazol...)
Affinity DataIC50: 16nMT: 2°CAssay Description:The reactions employed a common peptide substrate, LCB-EQEDEPEGDYFEWLW-NH2 (in-house). The basic assay protocol is as follows: First, 250 nL of dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Beijing Forelandpharma

US Patent
LigandPNGBDBM228210(US10047084, 9 | 3-methyl-8-(6-(1-methyl-1H-pyrazol...)
Affinity DataIC50: 550nMAssay Description:The inhibition of the mTOR protein kinase activity by the compounds was determined by the enzymatic activity assay in vitro. The detection kit suppli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details
Go to US Patent