BDBM22821 7-methyl-2,3-dihydro-1H-indole-2,3-dione::Isatin-based compound, 41

SMILES Cc1cccc2c1NC(=O)C2=O

InChI Key InChIKey=UEHZKEABUOAZSH-UHFFFAOYSA-N

Data  5 KI  1 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 22821   

TargetD-amino-acid oxidase(Pig)
Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM22821(7-methyl-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKd:  8.23E+3nMAssay Description:Binding affinity to pig kidney DAAO by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Human)
Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM22821(7-methyl-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataIC50: 1.31E+4nMAssay Description:Inhibition of human DAAO using D-KYN as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins by FP-6300-based flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
St. Jude Research Hospital

LigandPNGBDBM22821(7-methyl-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
St. Jude Research Hospital

LigandPNGBDBM22821(7-methyl-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Rabbit)
St. Jude Research Hospital

LigandPNGBDBM22821(7-methyl-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
St. Jude Research Hospital

LigandPNGBDBM22821(7-methyl-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCholinesterase(Human)
St. Jude Research Hospital

LigandPNGBDBM22821(7-methyl-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed