BDBM228178 1-(2-{(R)-2-Methyl-4-[2-trifluoromethyl-4-(2-trifluoromethyl-pyrimidin-5-yl)-thiazol-5-yl]-piperazin-1-yl}-2-oxo-ethyl)-1H-[1,2,4]triazole-3-carboxylic acid amide::US10047080, 5

SMILES CC1CNCC(N1C(=O)Cn1cnc(n1)C(N)=O)c1sc(cc1-c1cnc(nc1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=UCRKXMJQTOQXOI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 228178   

TargetC-X-C chemokine receptor type 3(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM228178(1-(2-{(R)-2-Methyl-4-[2-trifluoromethyl-4-(2-trifl...)
Affinity DataIC50: 12nMpH: 7.4Assay Description:The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details
Go to US Patent

TargetC-X-C chemokine receptor type 3(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM228178(1-(2-{(R)-2-Methyl-4-[2-trifluoromethyl-4-(2-trifl...)
Affinity DataIC50: 1.71E+3nMAssay Description:Stock solutions of test compounds are made up at a concentration of 10 mM in DMSO, and serially diluted in PBS containing 0.5% BSA to concentrations ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details
Go to US Patent