BDBM228170 (S)-N-(3-(6-amino-2-(difluoromethyl)-3,3-difluoro-2,3,4,5-tetrahydropyridin-2-yl)-4-fluorophenyl)-5-cyano-3-methylpicolinamide (Compound 11)::BDBM230875::US10045974, 11::US10603310, Compound 11

SMILES Cc1cc(cnc1C(=O)Nc1ccc(F)c(c1)[C@]1(N=C(N)CCC1(F)F)C(F)F)C#N

InChI Key InChIKey=BMEKAAPGFZBYOC-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 228170   

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM228170(BDBM230875 | US10045974, 11 | (S)-N-(3-(6-amino-2-...)
Affinity DataKi:  7.80nM ΔG°:  -11.1kcal/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2017
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM228170(BDBM230875 | US10045974, 11 | (S)-N-(3-(6-amino-2-...)
Affinity DataKi:  7.80nM ΔG°:  -11.1kcal/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM228170(BDBM230875 | US10045974, 11 | (S)-N-(3-(6-amino-2-...)
Affinity DataKi:  7.80nMAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent