BDBM2279 2-[(benzenesulfinyl)methyl]-3-(phenylsulfanyl)-1H-indole::5Cl3PhS-2IndolCONH2 inhibitor 5a

SMILES O=S(Cc1[nH]c2ccccc2c1Sc1ccccc1)c1ccccc1

InChI Key InChIKey=WEJMICDBYIOXOH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 2279   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM2279(2-[(benzenesulfinyl)methyl]-3-(phenylsulfanyl)-1H-...)
Affinity DataIC50: 63nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027,K690N]/[588-1147,K690N](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM2279(2-[(benzenesulfinyl)methyl]-3-(phenylsulfanyl)-1H-...)
Affinity DataIC50: 2.57E+3nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM2279(2-[(benzenesulfinyl)methyl]-3-(phenylsulfanyl)-1H-...)
Affinity DataIC50: 2.99E+3nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2004
Entry Details Article
PubMed