BDBM2278 3-(benzenesulfonyl)-5-chloro-1H-indole-2-carboxamide::5-Chloro-3-(phenylsulfonyl)-2-indolecarboxamide::5Cl3PhSO2-2IndolCONH2::L-737,126

SMILES NC(=O)c1[nH]c2ccc(Cl)cc2c1S(=O)(=O)c1ccccc1

InChI Key InChIKey=KHJNUJLYIHQWQI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 2278   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM2278(5Cl3PhSO2-2IndolCONH2 | 3-(benzenesulfonyl)-5-chlo...)
Affinity DataIC50: 3nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027,K690N]/[588-1147,K690N](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM2278(5Cl3PhSO2-2IndolCONH2 | 3-(benzenesulfonyl)-5-chlo...)
Affinity DataIC50: 116nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM2278(5Cl3PhSO2-2IndolCONH2 | 3-(benzenesulfonyl)-5-chlo...)
Affinity DataIC50: 71nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM2278(5Cl3PhSO2-2IndolCONH2 | 3-(benzenesulfonyl)-5-chlo...)
Affinity DataIC50: 25nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027,K690N]/[588-1147,K690N](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM2278(5Cl3PhSO2-2IndolCONH2 | 3-(benzenesulfonyl)-5-chlo...)
Affinity DataIC50: 5.00E+3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM2278(5Cl3PhSO2-2IndolCONH2 | 3-(benzenesulfonyl)-5-chlo...)
Affinity DataIC50: 160nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2004
Entry Details Article
PubMed
TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
Merck

Curated by ChEMBL
LigandPNGBDBM2278(5Cl3PhSO2-2IndolCONH2 | 3-(benzenesulfonyl)-5-chlo...)
Affinity DataIC50: 116nMAssay Description:Inhibition of HIV NL43 recombinant reverse transcriptase K103N mutant by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed