BDBM227795 BDBM227897::US10047096, 58::rac-4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-{[3-(2-hydroxyethyl)piperidin-1-yl]methyl}-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one

SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CN5CCCC(CCO)C5)cc4NC(=O)c23)cc1O

InChI Key InChIKey=FIGALARIXLDOBI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 227795   

TargetVascular endothelial growth factor receptor 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227795(US10047096, 58 | rac-4-[(2-Fluoro-5-hydroxy-4-meth...)
Affinity DataIC50: 0.548nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2018
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227795(US10047096, 58 | rac-4-[(2-Fluoro-5-hydroxy-4-meth...)
Affinity DataIC50: 2.05nMpH: 7.5 T: 2°CAssay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFR (amino acids R561-L1106), expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2018
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227795(US10047096, 58 | rac-4-[(2-Fluoro-5-hydroxy-4-meth...)
Affinity DataIC50: 0.831nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2018
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227795(US10047096, 58 | rac-4-[(2-Fluoro-5-hydroxy-4-meth...)
Affinity DataIC50: 1.16nMpH: 7.5 T: 2°CAssay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFR (amino acids R561-L1106), expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2018
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227795(US10047096, 58 | rac-4-[(2-Fluoro-5-hydroxy-4-meth...)
Affinity DataIC50: 0.833nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2018
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227795(US10047096, 58 | rac-4-[(2-Fluoro-5-hydroxy-4-meth...)
Affinity DataIC50: 1.28nMpH: 7.5 T: 2°CAssay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFR (amino acids R561-L1106), expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2018
Entry Details
Go to US Patent