BDBM227711 US9556157, 2::n-((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)-5-(((trans)-4-(dimethylamino)cyclohexyl)(ethyl)amino)-4-methylthiophene-3-carboxamide

SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)[nH]c(C)cc2=O)c1C

InChI Key InChIKey=VKVMZGLDNBSRKZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 227711   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM227711(US9556157, 2 | n-((2,6-dimethyl-4-oxo-1,4-dihydrop...)
Affinity DataIC50: 32nMpH: 8.0 T: 2°CAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM227711(US9556157, 2 | n-((2,6-dimethyl-4-oxo-1,4-dihydrop...)
Affinity DataIC50: 100nMpH: 8.0 T: 2°CAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
Go to US Patent