BDBM227696 2-{1-[6-(5-chloropyridin- 3-yl)-7-[(trans-4- methylcyclohexyl)methyl]- 2-(5-oxo-4,5-dihydro- 1,2,4-oxadiazol-3-yl)-7h- purin-8-yl]-1- methoxyethyl}benzonitrile (enantiomer 1)::US9540377, 23.111::US9540377, 23.112

SMILES COC(C)(c1nc2nc(nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1)c1ccccc1C#N

InChI Key InChIKey=DEDPWBNKWRTFFJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 227696   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM227696(US9540377, 23.111 | 2-{1-[6-(5-chloropyridin- 3-yl...)
Affinity DataIC50: 0.435nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM227696(US9540377, 23.111 | 2-{1-[6-(5-chloropyridin- 3-yl...)
Affinity DataIC50: 2.77nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
Go to US Patent