BDBM226493 US9328096, 186

SMILES NC(=O)c1cc(NC(=O)c2cc(-c3ccccn3)c(cc2Cl)C2CC2)n(n1)-c1ccccc1

InChI Key InChIKey=TUOHPXSGIUGQKB-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 226493   

TargetHigh affinity nerve growth factor receptor [441-796](Human)
Pfizer

US Patent

LigandBDBM226493(US9328096, 186)Copy SMILESCopy InChI

Affinity DataIC50: 93.3nMT: 2°CAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/15/2017
Entry Details
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TargetHigh affinity nerve growth factor receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM226493(US9328096, 186)Copy SMILESCopy InChI

Affinity DataIC50: 93nMAssay Description:Antagonist activity at prolink-tagged TrkA (unknown origin) expressed in cells assessed as inhibition of NGF-induced receptor phosphorylation by meas...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/18/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL