BDBM226447 US9328096, 140

SMILES OCCNC(=O)c1cc(NC(=O)c2cc(-c3ccccn3)c(cc2Cl)C(F)(F)F)n(n1)-c1ccccc1

InChI Key InChIKey=AJAIIHXDXVNPCD-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 226447   

TargetHigh affinity nerve growth factor receptor [441-796](Human)
Pfizer

US Patent

LigandBDBM226447(US9328096, 140)Copy SMILESCopy InChI

Affinity DataIC50: 29.5nMT: 2°CAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoKEGGPC cidPC sidSimilars

In Depth
Date in BDB:
5/15/2017
Entry Details
Copy Entry DOIGo to US Patent

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TargetHigh affinity nerve growth factor receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM226447(US9328096, 140)Copy SMILESCopy InChI

Affinity DataIC50: 30nMAssay Description:Antagonist activity at prolink-tagged TrkA (unknown origin) expressed in cells assessed as inhibition of NGF-induced receptor phosphorylation by meas...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoKEGGPC cidPC sidSimilars

In Depth
Date in BDB:
2/18/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL