BDBM22574 2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}-N-[(2R)-1-hydroxy-4-(methylsulfanyl)butan-2-yl]acetamide::CHEMBL432260::alpha-substituted indomethacin ethanolamide, 14

SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)N[C@@H](CO)CCSC)c2c1

InChI Key InChIKey=PMLQJXADXWPWHU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 22574   

TargetProstaglandin G/H synthase 1(Sheep)
Michigan State University

LigandPNGBDBM22574(CHEMBL432260 | 2-{1-[(4-chlorophenyl)carbonyl]-5-m...)
Affinity DataIC50: 5.10E+4nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2008
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Michigan State University

LigandPNGBDBM22574(CHEMBL432260 | 2-{1-[(4-chlorophenyl)carbonyl]-5-m...)
Affinity DataIC50: 250nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2008
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Michigan State University

LigandPNGBDBM22574(CHEMBL432260 | 2-{1-[(4-chlorophenyl)carbonyl]-5-m...)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibitory concentration against prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Michigan State University

LigandPNGBDBM22574(CHEMBL432260 | 2-{1-[(4-chlorophenyl)carbonyl]-5-m...)
Affinity DataIC50: 250nMAssay Description:Inhibitory concentration against human prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed