BDBM22571 2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}-N-[(2S)-1-hydroxypropan-2-yl]acetamide::CHEMBL281847::alpha-substituted indomethacin ethanolamide, 7

SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)N[C@@H](C)CO)c2c1

InChI Key InChIKey=VDUMTSIKQQNNNR-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 22571   

TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibitory concentration against I92L mutant murine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 3.90E+5nMAssay Description:Inhibitory concentration against Y115L mutant murine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibitory concentration against H122N mutant murine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibitory concentration against R120A mutant murine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 1.60E+5nMAssay Description:Inhibitory concentration against l503F mutant murine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibitory concentration against S530A mutant murine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 2.20E+5nMAssay Description:Inhibitory concentration against V5231, mutant murine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibitory concentration against VRV, mutant murine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibitory concentration against F357L mutant murine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 1.70E+5nMAssay Description:Inhibitory concentration against wild type murine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibitory concentration against R120Q mutant murine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Michigan State University

LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 590nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2008
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 2.10E+5nMAssay Description:Inhibitory concentration against Y115L/S119V mutant murine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibitory concentration against V891 mutant murine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 2.20E+5nMAssay Description:Inhibitory concentration against E524L mutant murine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Michigan State University

LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 590nMAssay Description:Inhibitory concentration against ovine Prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 270nMAssay Description:Inhibitory concentration against human Prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 270nMAssay Description:Inhibitory concentration against human prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibitory concentration against S119V mutant murine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Michigan State University

LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 590nMAssay Description:Inhibitory concentration against prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM22571(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 270nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2008
Entry Details Article
PubMed