BDBM225122 US9328118, 23

SMILES FC(F)(F)c1cc(ccc1OCCC1CCNCC1)-c1nc(nc2n(CC3CCOC3)ccc12)C#N

InChI Key InChIKey=NBKBYLWQEXRZJJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 225122   

TargetCathepsin S(Human)
Astellas Pharma

US Patent
LigandPNGBDBM225122(US9328118, 23)
Affinity DataIC50: 1.90nMAssay Description:5 μL of a human cathepsin S enzyme (R&D1183-CY-010) was added to a 96-well plate so as to be 20 ng/well. Next, 10-fold dilution of the test comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
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TargetCathepsin S(Mouse)
Astellas Pharma

US Patent
LigandPNGBDBM225122(US9328118, 23)
Affinity DataIC50: 3nMAssay Description:First, spleen cells collected from C57BL/6 mice were seeded in a 96-well plate so as to be a 1× 105 cells/well, then, 5-fold dilution of 10 mM DMSO s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent