BDBM224645 US9328111, 18

SMILES O=c1[nH]nc2c3CCN(Cc4ccccc4)Cc3[nH]c3cccc1c23

InChI Key InChIKey=GFUWRTZMZMICED-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 224645   

TargetPoly [ADP-ribose] polymerase 1(Human)
Beigene

US Patent
LigandPNGBDBM224645(US9328111, 18)
Affinity DataIC50: 8.70nMpH: 8.0Assay Description:PARP1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP1 was pre-incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
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TargetPoly [ADP-ribose] polymerase 2(Human)
Beigene

US Patent
LigandPNGBDBM224645(US9328111, 18)
Affinity DataIC50: 1.5nMAssay Description:PARP2 and PARP3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
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TargetPoly [ADP-ribose] polymerase 2(Human)
Beigene

US Patent
LigandPNGBDBM224645(US9328111, 18)
Affinity DataIC50: 2.00E+3nMAssay Description:PARP2 and PARP3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Beigene

US Patent
LigandPNGBDBM224645(US9328111, 18)
Affinity DataIC50: 43nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent