BDBM224481 US10080750, Compound 159::US9321760, 159::US9662330, Compound 159

SMILES NCC(N1CCN(CC1)c1ncnc(N)c1-c1ccc(F)cc1)c1ccc(F)cc1

InChI Key InChIKey=QOAJNEZEOFGNDX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 224481   

TargetRibosomal protein S6 kinase beta-1(Human)
Merck Patent

US Patent
LigandPNGBDBM224481(US9321760, 159 | US10080750, Compound 159 | US9662...)
Affinity DataIC50: 4.40nMpH: 7.5Assay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandPNGBDBM224481(US9321760, 159 | US10080750, Compound 159 | US9662...)
Affinity DataIC50: 4.40nMpH: 7.5Assay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetRibosomal protein S6 kinase beta-1(Human)
Merck Patent

US Patent
LigandPNGBDBM224481(US9321760, 159 | US10080750, Compound 159 | US9662...)
Affinity DataIC50: 4.40nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
Go to US Patent

TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM224481(US9321760, 159 | US10080750, Compound 159 | US9662...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed