BDBM224103 6-(3-chlorophenyl)-7- [(trans-4- methylcyclohexyl) methyl]-8-[(3r)-3- phenylmorpholin-4- yl]-7h-purine-2- carboxylic acid::US9540377, 16.22

SMILES C[C@H]1CC[C@H](Cn2c(nc3nc(nc(-c4cccc(Cl)c4)c23)C(O)=O)N2CCOC[C@H]2c2ccccc2)CC1

InChI Key InChIKey=VWJDPKRHKJMTOW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224103   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM224103(US9540377, 16.22 | 6-(3-chlorophenyl)-7- [(trans-4...)
Affinity DataIC50: 0.680nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
Go to US Patent