BDBM22406 2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octan-2-yl]-5-(3,4-dichlorophenyl)-1,3-thiazole::WIN 35,065-2 Analogue, 4i

SMILES CN1[C@H]2CC[C@@H]1[C@H]([C@H](C2)c1ccc(Cl)cc1)c1ncc(s1)-c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=MQFVMWBVJNBDJG-UHFFFAOYSA-N

Data  5 KI  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 22406   

TargetSodium-dependent dopamine transporter(Human)
Research Triangle Institute

LigandPNGBDBM22406(2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...)
Affinity DataKi:  66nM EC50:  416nMAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2008
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

LigandPNGBDBM22406(2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...)
Affinity DataKi:  380nM ΔG°:  -8.75kcal/molepH: 7.4 T: 2°CAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2008
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Research Triangle Institute

LigandPNGBDBM22406(2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...)
Affinity DataIC50: 440nMpH: 7.4 T: 2°CAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2008
Entry Details Article
PubMed
TargetTransporter(Rat)
Research Triangle Institute

LigandPNGBDBM22406(2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...)
Affinity DataKi: >2.00E+3nMAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2008
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Research Triangle Institute

LigandPNGBDBM22406(2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...)
Affinity DataKi:  2.30E+3nM EC50:  6.50E+3nMAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2008
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Research Triangle Institute

LigandPNGBDBM22406(2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...)
Affinity DataKi:  2.71E+3nM EC50:  5.30E+3nMAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2008
Entry Details Article
PubMed