BDBM224013 8-Mercaptoquinoline (8TQ)::US10005735, Example 8TQ

SMILES Sc1cccc2cccnc12

InChI Key InChIKey=MHTSJSRDFXZFHQ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 224013   

Target26S proteasome non-ATPase regulatory subunit 14(Human)
California Institute of Technology

LigandPNGBDBM224013(8-Mercaptoquinoline (8TQ) | US10005735, Example 8T...)
Affinity DataIC50: 2.40E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays were performed in low-volume 384-well solid black plates (Molecular Devices) in quadruplicate. The assays were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM224013(8-Mercaptoquinoline (8TQ) | US10005735, Example 8T...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human carbonic anhydrase-2 using p-nitrophenylacetate as substrate preincubated for 10 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM224013(8-Mercaptoquinoline (8TQ) | US10005735, Example 8T...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of recombinant human 5-LO expressed in baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM224013(8-Mercaptoquinoline (8TQ) | US10005735, Example 8T...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of recombinant human MMP2 catalytic domain (Tyr110 to Asp452 residues) expressed in yeast using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM224013(8-Mercaptoquinoline (8TQ) | US10005735, Example 8T...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus expression system using substrate 3 preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM224013(8-Mercaptoquinoline (8TQ) | US10005735, Example 8T...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of full length recombinant human C-terminal His/FLAG-tagged HDAC1 expressed in baculovirus expression system using substrate 3 preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
Target26S proteasome non-ATPase regulatory subunit 14(Human)
California Institute of Technology

LigandPNGBDBM224013(8-Mercaptoquinoline (8TQ) | US10005735, Example 8T...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM224013(8-Mercaptoquinoline (8TQ) | US10005735, Example 8T...)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of CSN5 (unknown origin) using SCFskp2-Nedd8OG as substrate after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
Target26S proteasome non-ATPase regulatory subunit 14(Human)
California Institute of Technology

LigandPNGBDBM224013(8-Mercaptoquinoline (8TQ) | US10005735, Example 8T...)
Affinity DataIC50: 2.80E+3nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
Go to US Patent