BDBM223681 3-(6-{[(1r)-1- cyclobutylethyl]amino}- 8-[2-(1-methoxy- 1- methylethyl)pyrrolidin- 1-yl]-7-[(trans-4- methylcyclohexyl) methyl]-7h-purin-2- yl)-1,2,4-oxadiazol- 5(2h)-one::US9540377, 11.107

SMILES COC(C)(C)C1CCCN1c1nc2nc(nc(N[C@H](C)C3CCC3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1

InChI Key InChIKey=RPEXSQZXYWFONN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 223681   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM223681(US9540377, 11.107 | 3-(6-{[(1r)-1- cyclobutylethyl...)
Affinity DataIC50: 0.507nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
Go to US Patent