BDBM223322 US9315520, 9::US9605007, Example 9::US9744173, Example 9

SMILES C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(F)cn2)cs1

InChI Key InChIKey=QQBRRRLRJBDPNK-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 223322   

TargetIsoform D of Beta-secretase 1 (BACE-I-432)(Human)
Pfizer

US Patent
LigandPNGBDBM223322(US9315520, 9 | US9605007, Example 9 | US9744173, E...)
Affinity DataIC50: 189nMpH: 4.5 T: 2°CAssay Description:The substrate is Biotin-GLTNIKTEEISEISY^EVEFR-C[Oregon Green]KK-OH. The BACE1 enzyme is affinity purified material from conditioned media of CHO-K1 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223322(US9315520, 9 | US9605007, Example 9 | US9744173, E...)
Affinity DataIC50: 189nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223322(US9315520, 9 | US9605007, Example 9 | US9744173, E...)
Affinity DataIC50: 189nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM223322(US9315520, 9 | US9605007, Example 9 | US9744173, E...)
Affinity DataIC50: 233nMAssay Description:Inhibition of human BACE2 using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon green]KK-OH as substrate after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCathepsin D(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM223322(US9315520, 9 | US9605007, Example 9 | US9744173, E...)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of Cathepsin D (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223322(US9315520, 9 | US9605007, Example 9 | US9744173, E...)
Affinity DataIC50: 229nMAssay Description:Inhibition of human BACE1 using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon green]KK-OH as substrate after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM223322(US9315520, 9 | US9605007, Example 9 | US9744173, E...)
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells for 5 mins at -80 mV holding potential by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223322(US9315520, 9 | US9605007, Example 9 | US9744173, E...)
Affinity DataIC50: 24nMAssay Description:Inhibition of BACE1 in human H4 cells transfected with wild type APP assessed as reduction in soluble portion of APPbeta level in cells incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed