BDBM222965 US9315514, 8

SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)[C@@]12CC[C@@]35C[C@@H]1[C@](C)(OCO2)C(C)(C)C

InChI Key

Data  1 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 222965   

TargetMu-type opioid receptor(Human)
Rhodes Technologies

US Patent
LigandPNGBDBM222965(US9315514, 8)
Affinity DataEC50:  85.4nMpH: 7.4 T: 2°CAssay Description:[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared in-house from a cell line expressing recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetKappa-type opioid receptor(Human)
Rhodes Technologies

US Patent
LigandPNGBDBM222965(US9315514, 8)
Affinity DataEC50:  855nMpH: 7.4 T: 2°CAssay Description:Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetKappa-type opioid receptor(Human)
Rhodes Technologies

US Patent
LigandPNGBDBM222965(US9315514, 8)
Affinity DataKi:  7.22nM ΔG°:  -11.1kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
Go to US Patent