BDBM222818 US11059766, WO2011128279 Ex. 109::US9315498, 109::WO2011128279, Example 109

SMILES CN1[C@H]2CCC[C@H]2N(C1=O)c1ccc(cn1)C#Cc1cccc(F)c1

InChI Key InChIKey=CXSRRWDESYDWAM-UHFFFAOYSA-N

Data  2 KI  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 222818   

TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM222818(US9315498, 109 | US11059766, WO2011128279 Ex. 109 ...)
Affinity DataEC50:  18nMT: 2°CAssay Description:A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 5(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM222818(US9315498, 109 | US11059766, WO2011128279 Ex. 109 ...)
Affinity DataEC50:  18nMAssay Description:A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 5(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM222818(US9315498, 109 | US11059766, WO2011128279 Ex. 109 ...)
Affinity DataEC50:  12nMAssay Description:A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 5(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM222818(US9315498, 109 | US11059766, WO2011128279 Ex. 109 ...)
Affinity DataEC50:  18nMAssay Description:For binding experiments, cDNA encoding human mGlu5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 5(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM222818(US9315498, 109 | US11059766, WO2011128279 Ex. 109 ...)
Affinity DataEC50:  18nMAssay Description:A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 5(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM222818(US9315498, 109 | US11059766, WO2011128279 Ex. 109 ...)
Affinity DataEC50:  12nMAssay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 5(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM222818(US9315498, 109 | US11059766, WO2011128279 Ex. 109 ...)
Affinity DataEC50:  18nMAssay Description:A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 5(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM222818(US9315498, 109 | US11059766, WO2011128279 Ex. 109 ...)
Affinity DataKi:  37nMAssay Description:For binding experiments, cDNA encoding human mGlu5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 5(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM222818(US9315498, 109 | US11059766, WO2011128279 Ex. 109 ...)
Affinity DataKi:  37nMAssay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent