BDBM222445 3-Chloro-N-[4-oxo-5-(2-oxoindolin-3-ylidene)-2-thioxothiazolidin-3-yl]benzo[b]thiophene-2-carboxamide (5i)

SMILES Clc1c(sc2ccccc12)C(=O)NN1C(=S)S\C(C1=O)=C1\C(=O)Nc2ccccc12

InChI Key InChIKey=XOGQTDIYEZUYBC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 222445   

TargetProstaglandin G/H synthase 1(Sheep)
Alexandria University

LigandPNGBDBM222445(3-Chloro-N-[4-oxo-5-(2-oxoindolin-3-ylidene)-2-thi...)
Affinity DataIC50: 5.90E+3nMAssay Description:All the newly synthesized compounds were screened for their ability to inhibit COX-1 and COX-2 enzymes. This was carried out using Cayman colorimetri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
Alexandria University

LigandPNGBDBM222445(3-Chloro-N-[4-oxo-5-(2-oxoindolin-3-ylidene)-2-thi...)
Affinity DataIC50: 1.56E+3nMAssay Description:All the newly synthesized compounds were screened for their ability to inhibit COX-1 and COX-2 enzymes. This was carried out using Cayman colorimetri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2017
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Alexandria University

LigandPNGBDBM222445(3-Chloro-N-[4-oxo-5-(2-oxoindolin-3-ylidene)-2-thi...)
Affinity DataIC50: 6.87E+3nMAssay Description:All the newly synthesized compounds were also evaluated in vitro for their ability to inhibit lipoxygenase enzyme. This was carried out using Abnova ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2017
Entry Details Article
PubMed