BDBM222443 3-Chloro-N-[5-(4-hydroxy-3-methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl]benzo [b]thiophene-2-carboxamide (5g)

SMILES COc1cc(\C=C2/SC(=S)N(NC(=O)c3sc4ccccc4c3Cl)C2=O)ccc1O

InChI Key InChIKey=DQIKJORLRWFRLD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 222443   

TargetProstaglandin G/H synthase 1(Sheep)
Alexandria University

LigandPNGBDBM222443(3-Chloro-N-[5-(4-hydroxy-3-methoxybenzylidene)-4-o...)
Affinity DataIC50: 1.04E+4nMAssay Description:All the newly synthesized compounds were screened for their ability to inhibit COX-1 and COX-2 enzymes. This was carried out using Cayman colorimetri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
Alexandria University

LigandPNGBDBM222443(3-Chloro-N-[5-(4-hydroxy-3-methoxybenzylidene)-4-o...)
Affinity DataIC50: 4.22E+3nMAssay Description:All the newly synthesized compounds were screened for their ability to inhibit COX-1 and COX-2 enzymes. This was carried out using Cayman colorimetri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2017
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Alexandria University

LigandPNGBDBM222443(3-Chloro-N-[5-(4-hydroxy-3-methoxybenzylidene)-4-o...)
Affinity DataIC50: 6.91E+3nMAssay Description:All the newly synthesized compounds were also evaluated in vitro for their ability to inhibit lipoxygenase enzyme. This was carried out using Abnova ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2017
Entry Details Article
PubMed