BDBM222437 3-Chloro-N-{5-[(1,3-diphenyl-1H-pyrazol-4-yl)methylene]-4-oxo-2-thioxothiazolidin-3-yl}benzo[b]thiophene-2-carboxamide (5a)

SMILES Clc1c(sc2ccccc12)C(=O)NN1C(=S)S\C(=C/c2cn(nc2-c2ccccc2)-c2ccccc2)C1=O

InChI Key InChIKey=IHLPCDZWFOJMCR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 222437   

TargetProstaglandin G/H synthase 1(Sheep)
Alexandria University

LigandPNGBDBM222437(3-Chloro-N-{5-[(1,3-diphenyl-1H-pyrazol-4-yl)methy...)
Affinity DataIC50: 5.10E+3nMAssay Description:All the newly synthesized compounds were screened for their ability to inhibit COX-1 and COX-2 enzymes. This was carried out using Cayman colorimetri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
Alexandria University

LigandPNGBDBM222437(3-Chloro-N-{5-[(1,3-diphenyl-1H-pyrazol-4-yl)methy...)
Affinity DataIC50: 1.49E+3nMAssay Description:All the newly synthesized compounds were screened for their ability to inhibit COX-1 and COX-2 enzymes. This was carried out using Cayman colorimetri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2017
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Alexandria University

LigandPNGBDBM222437(3-Chloro-N-{5-[(1,3-diphenyl-1H-pyrazol-4-yl)methy...)
Affinity DataIC50: 3.97E+3nMAssay Description:All the newly synthesized compounds were also evaluated in vitro for their ability to inhibit lipoxygenase enzyme. This was carried out using Abnova ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2017
Entry Details Article
PubMed