BDBM22227 (1S,2S)-2-(3-methyl-4-{5-[4-(propan-2-yloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}phenyl)cyclopropane-1-carboxylic acid::3-arylpropionic acid derivative, 18a

SMILES CC(C)Oc1ccc(cc1C(F)(F)F)-c1nc(no1)-c1ccc(cc1C)[C@H]1C[C@@H]1C(O)=O

InChI Key InChIKey=VNRPRIAXZVNSEY-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 22227   

TargetSphingosine 1-phosphate receptor 1(Human)
Merck Research Laboratories

LigandPNGBDBM22227((1S,2S)-2-(3-methyl-4-{5-[4-(propan-2-yloxy)-3-(tr...)
Affinity DataEC50:  0.210nMpH: 7.4 T: 2°CAssay Description:EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2008
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Research Laboratories

LigandPNGBDBM22227((1S,2S)-2-(3-methyl-4-{5-[4-(propan-2-yloxy)-3-(tr...)
Affinity DataEC50:  123nMpH: 7.4 T: 2°CAssay Description:EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2008
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22227((1S,2S)-2-(3-methyl-4-{5-[4-(propan-2-yloxy)-3-(tr...)
Affinity DataEC50:  5.10nMpH: 7.4 T: 2°CAssay Description:EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2008
Entry Details Article
PubMed