BDBM221254 US9303015, 28

SMILES CCN(CC)c1nc2ccc(cc2c(c1Oc1ccc(Cl)cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(OC)nc1

InChI Key InChIKey=FZNXQPHQEMTZMH-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 221254   

TargetNuclear receptor ROR-gamma [258-518](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221254(US9303015, 28)
Affinity DataKd:  72nMpH: 7.0 T: 2°CAssay Description:ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
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TargetNuclear receptor ROR-gamma [258-518,Y502F](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221254(US9303015, 28)
Affinity DataIC50: 110nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
Go to US Patent