BDBM221253 US9303015, 27a::US9303015, 27b::US9303015, 27c

SMILES CCN(CC)c1nc2ccc(cc2c(c1Oc1ccc(Cl)cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F

InChI Key InChIKey=LTFNIYSAZCKYLQ-UHFFFAOYSA-N

Data  3 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 221253   

TargetNuclear receptor ROR-gamma [258-518](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221253(US9303015, 27c | US9303015, 27b | US9303015, 27a)
Affinity DataKd:  75nMpH: 7.0 T: 2°CAssay Description:ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma [258-518](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221253(US9303015, 27c | US9303015, 27b | US9303015, 27a)
Affinity DataKd:  14nMpH: 7.0 T: 2°CAssay Description:ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma [258-518](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221253(US9303015, 27c | US9303015, 27b | US9303015, 27a)
Affinity DataKd:  1.40E+3nMpH: 7.0 T: 2°CAssay Description:ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma [258-518,Y502F](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221253(US9303015, 27c | US9303015, 27b | US9303015, 27a)
Affinity DataIC50: 210nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma [258-518,Y502F](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221253(US9303015, 27c | US9303015, 27b | US9303015, 27a)
Affinity DataIC50: 10nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma [258-518,Y502F](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221253(US9303015, 27c | US9303015, 27b | US9303015, 27a)
Affinity DataIC50: 95nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
Go to US Patent