BDBM22106 7-{[(2R,4S)-2,4-bis(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one::Azetidine based compound, 40

SMILES OC[C@H]1C[C@@H](CO)N1Cc1c[nH]c2c1nc[nH]c2=O

InChI Key InChIKey=ZZDOJITUEXBERC-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 22106   

TargetPurine nucleoside phosphorylase(Human)
Industrial Research

LigandPNGBDBM22106(7-{[(2R,4S)-2,4-bis(hydroxymethyl)azetidin-1-yl]me...)
Affinity DataKi:  12.9nM ΔG°:  -10.6kcal/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Bovine)
Industrial Research

LigandPNGBDBM22106(7-{[(2R,4S)-2,4-bis(hydroxymethyl)azetidin-1-yl]me...)
Affinity DataKi:  16nM ΔG°:  -10.5kcal/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

LigandPNGBDBM22106(7-{[(2R,4S)-2,4-bis(hydroxymethyl)azetidin-1-yl]me...)
Affinity DataKi:  1.29E+3nM ΔG°:  -7.95kcal/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed