BDBM21922 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(2H-1,2,3,4-tetrazol-5-ylmethyl)amino]quinoline-3-carbonitrile::Cyanoquinoline, 35

SMILES Fc1ccc(Nc2c(cnc3c(Cl)cc(NCc4nnn[nH]4)cc23)C#N)cc1Cl

InChI Key InChIKey=IPSFZCMYKQHAMQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 21922   

LigandPNGBDBM21922(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(2H...)
Affinity DataIC50: 2nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed