BDBM21899 8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol-4-ylmethyl)amino]quinoline-3-carbonitrile::Cyanoquinoline, 12

SMILES Fc1ccc(Nc2c(cnc3c(Br)cc(NCc4cnc[nH]4)cc23)C#N)cc1Cl

InChI Key InChIKey=SKFFXBWGYMDLSC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 21899   

LigandPNGBDBM21899(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-...)
Affinity DataIC50: 10nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

LigandPNGBDBM21899(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-...)
Affinity DataIC50: 3.30E+3nMAssay Description:EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed