BDBM218902 US9303033, I3, Table 12A, Compound 4

SMILES CN(C)c1cc(NC2CC2)n2ncc(\C=C3/SC(=O)NC3=O)c2n1

InChI Key InChIKey=MYRPEVBCFHHODE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 218902   

TargetCasein kinase II subunit alpha/beta(Human)
Senhwa Biosciences

US Patent
LigandPNGBDBM218902(US9303033, I3, Table 12A, Compound 4)
Affinity DataIC50: 100nMpH: 7.2Assay Description:In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2017
Entry Details
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TargetCasein kinase II subunit beta(Human)
Senhwa Biosciences

US Patent
LigandPNGBDBM218902(US9303033, I3, Table 12A, Compound 4)
Affinity DataIC50: 876nMpH: 7.0Assay Description:5 uM ATP: Test compounds dissolved and diluted in DMSO (2 μl) were added to a reaction mixture comprising 10 μl of 5× Reaction Buffer (40 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Senhwa Biosciences

US Patent
LigandPNGBDBM218902(US9303033, I3, Table 12A, Compound 4)
Affinity DataIC50: 2.50E+3nMpH: 7.0Assay Description:30 uM ATP: In a final reaction volume of 50 ul, recombinant PIM-1 (1 ng) was incubated with 12 mM MOPS pH 7.0, 0.4 mM EDTA, glycerol 1%, brij 35 0.00...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2017
Entry Details
Go to US Patent