BDBM218227 BDBM50531386::US9249087, Table 1 , Compound 4

SMILES Cc1c(CN)c2ccccc2n1-c1ccc(cc1)C(=O)NO

InChI Key InChIKey=MOIUUPNKOGSHCT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 218227   

TargetHistone deacetylase 1(Human)
University of Illinois

US Patent
LigandPNGBDBM218227(BDBM50531386 | US9249087, Table 1 , Compound 4)
Affinity DataIC50: 3.09E+3nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2017
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
University of Illinois

US Patent
LigandPNGBDBM218227(BDBM50531386 | US9249087, Table 1 , Compound 4)
Affinity DataIC50: 1.46nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2017
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
University of Illinois

US Patent
LigandPNGBDBM218227(BDBM50531386 | US9249087, Table 1 , Compound 4)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant full-length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells using fluorescent-labelled...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed