BDBM21799 2-[(1S)-5-[3-(4-{4H,5H,6H-cyclopenta[d][1,3]thiazol-2-yl}-2-methoxyphenoxy)propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid::Indanylacetic Acid Analog, 34n

SMILES COc1cc(ccc1OCCCOc1ccc2[C@H](CC(O)=O)CCc2c1)-c1nc2CCCc2s1

InChI Key InChIKey=IELCDGLGXNKKIF-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 21799   

TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21799(2-[(1S)-5-[3-(4-{4H,5H,6H-cyclopenta[d][1,3]thiazo...)
Affinity DataEC50:  53nMT: 2°CAssay Description:Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21799(2-[(1S)-5-[3-(4-{4H,5H,6H-cyclopenta[d][1,3]thiazo...)
Affinity DataEC50:  4.10nMT: 2°CAssay Description:Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21799(2-[(1S)-5-[3-(4-{4H,5H,6H-cyclopenta[d][1,3]thiazo...)
Affinity DataEC50:  116nMT: 2°CAssay Description:Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21799(2-[(1S)-5-[3-(4-{4H,5H,6H-cyclopenta[d][1,3]thiazo...)
Affinity DataEC50:  2.44E+8nMAssay Description:Agonist activity at GST-tagged Homo sapiens (human) PPARdelta ligand binding domain after 2 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21799(2-[(1S)-5-[3-(4-{4H,5H,6H-cyclopenta[d][1,3]thiazo...)
Affinity DataEC50:  8.71E+6nMAssay Description:Agonist activity at Homo sapiens (human) PPARgamma expressed in mouse 3T3-L1 cells incubated for 2 days followed by compound wash out measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21799(2-[(1S)-5-[3-(4-{4H,5H,6H-cyclopenta[d][1,3]thiazo...)
Affinity DataEC50:  1.89E+7nMAssay Description:Agonist activity at GST-tagged Homo sapiens (human) PPARalpha ligand binding domain after 2 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article