BDBM21755 2-[(1S)-5-{3-[4-(trifluoromethyl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid::Indanylacetic Acid Analog, 17c

SMILES OC(=O)C[C@@H]1CCc2cc(OCCCOc3ccc(cc3)C(F)(F)F)ccc12

InChI Key InChIKey=CATHVUDVAOYDLM-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 21755   

TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21755(2-[(1S)-5-{3-[4-(trifluoromethyl)phenoxy]propoxy}-...)
Affinity DataEC50:  1.61E+3nMpH: 7.4 T: 2°CAssay Description:Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21755(2-[(1S)-5-{3-[4-(trifluoromethyl)phenoxy]propoxy}-...)
Affinity DataEC50:  4.20nMT: 2°CAssay Description:Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21755(2-[(1S)-5-{3-[4-(trifluoromethyl)phenoxy]propoxy}-...)
Affinity DataEC50:  5.58E+3nMT: 2°CAssay Description:Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21755(2-[(1S)-5-{3-[4-(trifluoromethyl)phenoxy]propoxy}-...)
Affinity DataEC50:  1.82E+5nMAssay Description:Agonist activity at Homo sapiens (human) PPARgamma expressed in mouse 3T3-L1 cells incubated for 2 days followed by compound wash out measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetPeroxisome proliferator-activated receptor delta(Human)
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21755(2-[(1S)-5-{3-[4-(trifluoromethyl)phenoxy]propoxy}-...)
Affinity DataEC50:  2.38E+8nMAssay Description:Agonist activity at GST-tagged Homo sapiens (human) PPARdelta ligand binding domain after 2 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21755(2-[(1S)-5-{3-[4-(trifluoromethyl)phenoxy]propoxy}-...)
Affinity DataEC50:  6.21E+5nMAssay Description:Agonist activity at GST-tagged Homo sapiens (human) PPARalpha ligand binding domain after 2 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article