BDBM215631 US9296745, 198

SMILES C[C@@H](c1nc2cnc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1)n1cc(Cl)cn1

InChI Key InChIKey=VKZMFONLOPNWIE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 215631   

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM215631(US9296745, 198)
Affinity DataIC50: 43nMpH: 7.4 T: 2°CAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2017
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM215631(US9296745, 198)
Affinity DataIC50: 7.80nMAssay Description:For evaluation of the effects of DGAT2 inhibitors in a cell-based setting, cryopreserved human hepatocytes (Lot QOC, Celsis, Chicago, Ill.) were thaw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2017
Entry Details
Go to US Patent