BDBM21369 6-[4-(2-methylphenyl)piperazin-1-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide::CHEMBL222755::Piperazinehexanamide derivative, 7

SMILES Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc23)CC1

InChI Key InChIKey=JINXBCRENWAIPY-UHFFFAOYSA-N

Data  8 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 21369   

Target5-hydroxytryptamine receptor 7(Human)
Università

Curated by ChEMBL
LigandPNGBDBM21369(CHEMBL222755 | 6-[4-(2-methylphenyl)piperazin-1-yl...)
Affinity DataEC50:  1.82E+3nMAssay Description:Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM21369(CHEMBL222755 | 6-[4-(2-methylphenyl)piperazin-1-yl...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM21369(CHEMBL222755 | 6-[4-(2-methylphenyl)piperazin-1-yl...)
Affinity DataKi:  15.2nM ΔG°:  -11.1kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM21369(CHEMBL222755 | 6-[4-(2-methylphenyl)piperazin-1-yl...)
Affinity DataKi:  15.2nMAssay Description:Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Universita Degli Studi Di Bari

LigandPNGBDBM21369(CHEMBL222755 | 6-[4-(2-methylphenyl)piperazin-1-yl...)
Affinity DataKi:  143nMAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21369(CHEMBL222755 | 6-[4-(2-methylphenyl)piperazin-1-yl...)
Affinity DataKi:  262nMAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21369(CHEMBL222755 | 6-[4-(2-methylphenyl)piperazin-1-yl...)
Affinity DataKi:  262nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in Wistar Han rat cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Universita Degli Studi Di Bari

LigandPNGBDBM21369(CHEMBL222755 | 6-[4-(2-methylphenyl)piperazin-1-yl...)
Affinity DataKi:  279nMAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Università

Curated by ChEMBL
LigandPNGBDBM21369(CHEMBL222755 | 6-[4-(2-methylphenyl)piperazin-1-yl...)
Affinity DataKi:  279nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in Wistar Han rat hippocampal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed