BDBM21339 6-Methyl-uridine 5-O-Monophosphate::C6-Uridine Derivative, 16::JMC521648 Compound 38::{[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy}phosphonic acid

SMILES CC1=CC(=O)NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O

InChI Key InChIKey=CHBBJHPQYVYKFI-UHFFFAOYSA-N

Data  4 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 21339   

TargetOrotidine-5'-phosphate decarboxylase(Plasmodium vivax)
Toronto General Research Institute

LigandPNGBDBM21339(6-Methyl-uridine 5-O-Monophosphate | JMC521648 Com...)
Affinity DataKi:  2.24E+4nMpH: 7.5Assay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2008
Entry Details Article
PubMed
TargetOrotidine-5'-phosphate decarboxylase(malaria parasite P. falciparum)
Toronto General Research Institute

LigandPNGBDBM21339(6-Methyl-uridine 5-O-Monophosphate | JMC521648 Com...)
Affinity DataKi:  3.41E+4nM ΔG°:  -6.34kcal/molepH: 7.5 T: 2°CAssay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2008
Entry Details Article
PubMed
TargetOrotidine 5'-phosphate decarboxylase(Methanobacterium thermoautotrophicum)
Toronto General Research Institute

LigandPNGBDBM21339(6-Methyl-uridine 5-O-Monophosphate | JMC521648 Com...)
Affinity DataKi:  1.34E+5nM ΔG°:  -5.81kcal/molepH: 7.5 T: 2°CAssay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOrotidine 5'-phosphate decarboxylase(Methanobacterium thermoautotrophicum)
Toronto General Research Institute

LigandPNGBDBM21339(6-Methyl-uridine 5-O-Monophosphate | JMC521648 Com...)
Affinity DataKi:  1.34E+5nM ΔG°:  -5.81kcal/molepH: 7.5 T: 2°CAssay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)