BDBM213122 US9278960, 8-29::US9636337, 8-29

SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(CCc3cnc(C)nc3)ccc12)C(N)=O

InChI Key InChIKey=YFISEEHEDYLAHH-UHFFFAOYSA-N

Data  2 KI  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 213122   

LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 6nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 6nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 6nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 3(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 3.00E+4nMAssay Description:Negative allosteric modulation of mGlu3R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 146nMAssay Description:Negative allosteric modulation of mGlu2R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 3.00E+4nMAssay Description:Binding affinity to mGluR1 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 1.90E+4nMAssay Description:Binding affinity to mGluR3 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 5.90nMAssay Description:Binding affinity to mGluR2 (unknown origin) FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 3.00E+4nMAssay Description:Binding affinity to mGluR4 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 3.00E+4nMAssay Description:Binding affinity to mGluR5 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 9.83E+3nMAssay Description:Binding affinity to mGluR6 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 2.67E+4nMAssay Description:Binding affinity to mGluR8 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataKi:  0.190nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataKi:  2.26E+3nMAssay Description:Binding affinity to guinea pig adenosine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed