BDBM212934 US9278960, 4-9::US9663506, Example 4-9

SMILES C[C@@H]1CN(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2cnn(C)c2)C[C@@H](O1)C(F)(F)F

InChI Key InChIKey=KTYWQIWONODXST-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 212934   

LigandPNGBDBM212934(US9278960, 4-9 | US9663506, Example 4-9)
Affinity DataIC50: 11nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM212934(US9278960, 4-9 | US9663506, Example 4-9)
Affinity DataIC50: 11nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM212934(US9278960, 4-9 | US9663506, Example 4-9)
Affinity DataIC50: 11nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent

LigandPNGBDBM212934(US9278960, 4-9 | US9663506, Example 4-9)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of NaV 1.5 channel (unknown origin) by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed