BDBM212577 US10155731, Example 268::US9278944, 268

SMILES COC(=O)NCCCn1nc([C@@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2cccnc12

InChI Key InChIKey=IGXZOTGJSKGMAP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 212577   

TargetRenin(Human)
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM212577(US9278944, 268 | US10155731, Example 268)
Affinity DataIC50: 3.60nMAssay Description:A substrate of synthetic peptide (Nma-KHPFHLVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotome...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2017
Entry Details
Go to US Patent

TargetRenin(Human)
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM212577(US9278944, 268 | US10155731, Example 268)
Affinity DataIC50: 3.60nMAssay Description:A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
Go to US Patent

TargetRenin(Human)
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM212577(US9278944, 268 | US10155731, Example 268)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human recombinant renin (67 to 406 residues) expressed in HEK293 cells using Nma-Lys-His-Pro-Phe-His-Leu-Val-Ile-His-Lys-Dnp as fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetRenin(Human)
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM212577(US9278944, 268 | US10155731, Example 268)
Affinity DataIC50: 1.40nMAssay Description:Displacement of 125I-labeled angiotensin I from from human plasma renin by gamma counter based competitive radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed