BDBM212272 (R)-(4-(4-((6-(6-aminopyrazin-2-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)morpholin-2-yl)methanol:::US10828299, Example Ex.-3::US10342794, Example Ex.-3::US11517570, Example Ex.-3::US9290505, Ex.-3::US9504684, Ex.-3::US9931338, Ex.-3

SMILES Nc1cncc(n1)-c1cn2ccnc2c(Nc2ccc(cc2)N2CCO[C@@H](CO)C2)n1

InChI Key InChIKey=YMHAMCHFUTYGTR-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 212272   

TargetCD63 antigen(Human)
Gilead Sciences

US Patent
LigandPNGBDBM212272(US9504684, Ex.-3 | (R)-(4-(4-((6-(6-aminopyrazin-2...)
Affinity DataIC50: 33nMpH: 7.0Assay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Gilead Sciences

US Patent
LigandPNGBDBM212272(US9504684, Ex.-3 | (R)-(4-(4-((6-(6-aminopyrazin-2...)
Affinity DataIC50: 13.3nMpH: 7.0Assay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Gilead Sciences

US Patent
LigandPNGBDBM212272(US9504684, Ex.-3 | (R)-(4-(4-((6-(6-aminopyrazin-2...)
Affinity DataIC50: 13.3nMpH: 7.0 T: 2°CAssay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Gilead Sciences

US Patent
LigandPNGBDBM212272(US9504684, Ex.-3 | (R)-(4-(4-((6-(6-aminopyrazin-2...)
Affinity DataIC50: 13.3nMAssay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Gilead Sciences

US Patent
LigandPNGBDBM212272(US9504684, Ex.-3 | (R)-(4-(4-((6-(6-aminopyrazin-2...)
Affinity DataIC50: 13.3nMAssay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Gilead Sciences

US Patent
LigandPNGBDBM212272(US9504684, Ex.-3 | (R)-(4-(4-((6-(6-aminopyrazin-2...)
Affinity DataIC50: 13.3nMAssay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Gilead Sciences

US Patent
LigandPNGBDBM212272(US9504684, Ex.-3 | (R)-(4-(4-((6-(6-aminopyrazin-2...)
Affinity DataIC50: 13.3nMAssay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
Go to US Patent