BDBM211955 US9290481, 2.3

SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3c(Cl)c[nH]c23)n1

InChI Key InChIKey=NIOXPQFKHIQUEH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 211955   

TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM211955(US9290481, 2.3)
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Universita Degli Studi Di Palermo

Curated by ChEMBL
LigandPNGBDBM211955(US9290481, 2.3)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human SYK using 5-Fluo-Ahx-GAPDYENLQELNKK-Amid as substrate in presence of ATP by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
Universita Degli Studi Di Palermo

Curated by ChEMBL
LigandPNGBDBM211955(US9290481, 2.3)
Affinity DataIC50: 14nMAssay Description:Inhibition of SYK in human Ramos cells assessed as reduction in anti IgM-induced phosphorylation of BLNK by flow cytometry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed